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    STUDIA CHEMIA - Issue no. 3, Tom I / 2016  
         
  Article:   THIAZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY AGAINST CANDIDA SPECIES.

Authors:  MIHAELA SABOU, ADRIANA GROZAV, LIA MONICA JUNIE, MIRELA FLONTA, VALENTIN ZAHARIA, CASTELIA CRISTEA. 		 
       
         
  Abstract:   The antifungal activity of a series of thiazole, benzothiazole and benzothiazolyl-phenothiazine derivatives against Candida albicans and non-Candida albicans species causing invasive candidiasis was investigated using the diffusion method and the broth dilution procedure. Minimal inhibitory concentrations revealed antifungal activity against C. albicans, C. guillermondii, C. krusei and C. parapsilosis strains isolated from clinical materials (blood, urine and peritoneal fluids cultures). The tested hydrazine-thiazole derivatives showed promising antifungal activity against both fluconazole susceptible and resistive Candida species, while the benzothiazolyl-phenothiazine derivatives were not effective. 

Keywords: Thiazole, Benzothiazole, Phenothiazine, Candida species.
 
         
     
         
         
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